What if Serious Diseases Could Be Mimicked in Printed Organ Models? Bioprinting – Made of Light

Life itself is 3D, not 2D. Only structured, three-dimensional models can truly replicate the intricacies of living organisms.

Developing new medicines and treatments often involves extensive animal testing and clinical trials due to the complexity of replicating the 3D architecture of organs. Xolography offers a revolutionary way to print cells in defined 3D environments, enhancing the accuracy and efficacy of medical research.

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No Stress while Printing

A stationary gel matrix is solidified in a rapid print – not applying any stress to material nor cells and maximizing cell viability.

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Extra Soft Hydrogels

Printed materials may be exceptionally soft to resemble stiffness of almost all natural tissue structures.

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No Sedi­men­tation

The gelly hydrogel matrix embeds and nourishes the cells softly preventing uncontrolled sinking.

Status Quo

Bioprinting has focused on 2D methods, effective for skin but problematic for complex 3D organs. Layer-by-layer printing stresses cells and causes damage. Extrusion and DLP printers lack precision, while 2PP printers are too slow. What’s missing is a mix of diverse materials, cell-friendly processing, and precise, cost-effective large-scale printing.

With Xolography

Xolography excels in producing large objects with seamless vascularization and gentle cell handling. Sealable cuvettes enable sterile models and cleaner prints than open systems. This comprehensive approach and its printing speed positions Xolography to drive the next breakthrough in Bioprinting.

How Xolography opens up new potentials in Bioprinting

Bioprinters create structures that mimic the 3D architecture of organs, aiming to provide the ideal environment for cells. The main challenge in bioprinting today is vascularization – forming a fine network of blood vessels for oxygen and nutrient supply deep into tissue. Current models are limited in size and complexity, resembling cell clusters rather than full organs.

However, with advanced Bioprinting, patient-derived cells could be used for personalized drug testing, and printed organ models could deepen our understanding of diseases. Xolography holds promise for producing tissue implants from human stem cells, potentially revolutionizing regenerative medicine.

The greatest potential lies in saving time. Faster, more targeted studies accelerate the journey from hypothesis to therapy, ultimately saving lives.

Validated by Pionieers

The Castilho Lab

TU/e – Eindhoven University of Technology

Miguel Dias Castilho is Assistant Professor of Biomaterials design and processing at TU/e. The Castilho Lab combines advanced 3D printing technologies like Xolography and computational design, to develop instructive materials for regenerative medicine, particularly of musculoskeletal tissues, like bone.

The Leijten Lab

University of Twente

Jeroen Leijten, Associate Professor of Complex Tissue Engineering and principle investigator in the Department of Developmental BioEngineering of the TechMed Centre. Leijten’s main focus is to fully understand the functional properties of tissues such as cartilage, bone, muscle, lung, and pancreas in order to develop regenerative engineering strategies to repair tissues that do not heal by themselves.

The Duda / Petersen Lab

Charité

Georg Duda is interested in tissue regeneration – a term used to describe the body’s ability to completely restore tissue and its function following injury or illness. He always works with the latest cutting edge technology.

Help us shape the future of volumetric 3D Printing